Structural basis for the mutation-induced dysfunction of the human IL-15/IL-15α receptor complex-Reference-Cited by-同舟云学术

Structural basis for the mutation-induced dysfunction of the human IL-15/IL-15α receptor complex

Published:2023 Issue:4 Volume:25 Page:3020-3030
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Batool Zahida¹,Qureshi Urooj¹,Mushtaq Mamona²,Ahmed Sarfaraz³,Nur-e-Alam Mohammad³,Ul-Haq Zaheer¹²^ORCID

Affiliation:

1. H.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

2. Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

3. Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box. 2457, Riyadh 11451, Kingdom of Saudi Arabia

Abstract

In silico strategies offer a reliable, fast, and inexpensive, way compared to the clumsy in vitro approaches to boost understanding of the effect of amino acid substitution on the structure and consequently the associated function of proteins.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CP/D2CP03012H

Reference35 articles.

1. The Impact of Vitiligo on Quality of Life and Psychosocial Well-Being in a Nepalese Population

2. Mechanisms of melanocyte death in vitiligo

3. IL-15: a central regulator of celiac disease immunopathology

4. The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use