Double substitution leads to a highly polymorphic system in 5-methyl-2-m-tolylamino-benzoic acid-Reference-Cited by-同舟云学术

Double substitution leads to a highly polymorphic system in 5-methyl-2-m-tolylamino-benzoic acid

Published:2022 Issue:1 Volume:24 Page:95-106
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Zhoujin Yunping¹,Tao Yang¹,Zhou Panpan¹²^ORCID,Parkin Sean³^ORCID,Li Tonglei⁴^ORCID,Guo Ju¹,Yu Faquan¹^ORCID,Long Sihui¹^ORCID

Affiliation:

1. Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 206 1st Rd Optics Valley, East Lake New Technology Development District, Wuhan, Hubei, 430205 China

2. College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, China

3. Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, USA

4. Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA

Abstract

Substitution on both aromatic rings of fenamic acid led to a highly polymorphic system in 5-methyl-2-m-tolylamino-benzoic acid, in contrast to the two mono-substituted analogs, which had only one or two forms obtained.

Funder

Natural Science Foundation of Hubei Province

Hubei Key Laboratory of Novel Reactor and Green Chemistry Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CE/D1CE01219C

Reference42 articles.

1. Non-Steroidal Anti-Inflammatory Analgesics Other than Salicylates

2. Antipyretic, analgesic, anti-inflammatory and cytotoxic effects of four derivatives of salicylic acid and anthranilic acid in mice and rats

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4. A Comparative Clinical Study of a New Antirheumatic Agent, Tolfenamic Acid (Clotam), and Phenylbutazone in Rheumatoid Arthritis

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