A two-step continuous synthesis of α-ketoamides and α-amino ketones from 2° benzylic alcohols using hydrogen peroxide as an economic and benign oxidant-Reference-Cited by-同舟云学术

A two-step continuous synthesis of α-ketoamides and α-amino ketones from 2° benzylic alcohols using hydrogen peroxide as an economic and benign oxidant

Published:2016 Issue:30 Volume:6 Page:25167-25172
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Liu Chengkou¹²³⁴,Fang Zheng¹²³⁴,Yang Zhao⁵³⁴,Li Qingwen¹²³⁴,Guo Shiyu¹²³⁴,Guo Kai¹²³⁴⁶^ORCID

Affiliation:

1. College of Biotechnology and Pharmaceutical Engineering

2. Nanjing Tech University

3. Nanjing

4. China

5. College of Engineering China Pharmaceutical University

6. State Key Laboratory of Materials-Oriented Chemical Engineering

Abstract

A practical two-step flow synthesis of α-ketoamides and α-amino ketones via direct oxidative coupling between 2° benzylic alcohols and amines was developed.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA27653E

Reference62 articles.

1. Peptidyl α-Ketoamides with Nucleobases, Methylpiperazine, and Dimethylaminoalkyl Substituents as Calpain Inhibitors

2. Retinoid receptor subtype-selective modulators through synthetic modifications of RARγ agonists

3. Cocrystal Structures of Primed Side-Extending α-Ketoamide Inhibitors Reveal Novel Calpain-Inhibitor Aromatic Interactions

4. Design, Synthesis, and Biological Evaluation of Isoquinoline-1,3,4-trione Derivatives as Potent Caspase-3 Inhibitors

5. Synthesis of di- and tripeptide analogues containing α-ketoamide as a new core structure for inhibition of HIV-1 protease

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tailoring electrochemical and dielectric properties of SrO nanostructures through Cr-doping for energy storage applications;Materials Today Communications;2024-03

2. Atmospheric Oxygen Facilitated Oxidative Amidation to α-Ketoamides and Unusual One Carbon Degradative Amidation to N-Alkyl Amides;The Journal of Organic Chemistry;2023-10-26

3. I₂‐Mediated Oxidative Amidation of Aryl Methyl Ketones: Synthesis of Primary α‐Ketoamides Using Ammonium Carbamodithioate as Amine Surrogate;European Journal of Organic Chemistry;2023-04-27

4. Metal-Free Syntheses of α-Ketothioamide and α-Ketoamide Derivatives from Sulfoxonium Ylides;Organic Letters;2022-10-24

5. One-Pot Synthesis of α-Ketoamides from α-Keto Acids and Amines Using Ynamides as Coupling Reagents;The Journal of Organic Chemistry;2022-01-14