Novel 1,3,4-thiadiazole compounds as potential MAO-A inhibitors – design, synthesis, biological evaluation and molecular modelling-Reference-Cited by-同舟云学术

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Novel 1,3,4-thiadiazole compounds as potential MAO-A inhibitors – design, synthesis, biological evaluation and molecular modelling

Published:2020 Issue:9 Volume:11 Page:1063-1074
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Sağlık Begüm Nurpelin¹²³⁴⁵^ORCID,Kaya Çavuşoğlu Betül⁶²³⁴⁵^ORCID,Acar Çevik Ulviye¹²³⁴⁵^ORCID,Osmaniye Derya¹²³⁴⁵^ORCID,Levent Serkan¹²³⁴⁵^ORCID,Özkay Yusuf¹²³⁴⁵^ORCID,Kaplancıklı Zafer Asım¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry

2. Faculty of Pharmacy

3. Anadolu University

4. Eskişehir

5. Turkey

6. Doping and Narcotic Compounds Analysis Laboratory

Abstract

Compound 6b is a reversible and competitive hMAO-A inhibitor.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00150C

Reference59 articles.

1. Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies

2. Design, synthesis and biological evaluation of oxygenated chalcones as potent and selective MAO-B inhibitors

3. Novel C7-Substituted Coumarins as Selective Monoamine Oxidase Inhibitors: Discovery, Synthesis and Theoretical Simulation

4. Synthesis of 2‐Alkynyl‐ and2‐Amino‐12 H ‐benzothiazolo[2,3‐ b ]quinazolin‐12‐ones and Their Inhibitory Potential against Monoamine Oxidase A and B

5. Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors

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2. Emerging synthetic Strategies and Pharmacological Insights of 1,3,4-Thiadiazole Derivatives: A Comprehensive Review;Future Medicinal Chemistry;2024-02-14

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