Synthesis and potassium KV7 channel opening activity of thioether analogues of the analgesic flupirtine-Reference-Cited by-同舟云学术

Synthesis and potassium KV7 channel opening activity of thioether analogues of the analgesic flupirtine

Published:2018 Issue:45 Volume:16 Page:8695-8699
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bock Christian¹²³⁴⁵,Beirow Kristin¹²³⁴⁵,Surur Abdrrahman S.¹²³⁴⁵,Schulig Lukas¹²³⁴⁵,Bodtke Anja¹²³⁴⁵,Bednarski Patrick J.¹²³⁴⁵,Link Andreas¹²³⁴⁵^ORCID

Affiliation:

1. Pharmaceutical and Medicinal Chemistry

2. Institute of Pharmacy

3. University of Greifswald

4. 17487 Greifswald

5. Germany

Abstract

Benign by design: active sulfide-analogues of potassium channel opener flupirtine do not form reactive oxidation products in vitro.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02530D

Reference14 articles.

1. Flupirtine

2. Prescribers’ compliance is part of benefit-risk assessment of medicines and it can lead to failure of risk minimization measures and withdrawals of medicines

3. The impact of risk minimization measures on compliance and prescribing practices of flupirtine in Germany

4. Quantitative LC–MS/MS determination of flupirtine, its N-acetylated and two mercapturic acid derivatives in man

5. In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury

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