Nucleolin-targeted selenium nanocomposites with enhanced theranostic efficacy to antagonize glioblastoma-Reference-Cited by-同舟云学术

Nucleolin-targeted selenium nanocomposites with enhanced theranostic efficacy to antagonize glioblastoma

Published:2017 Issue:16 Volume:5 Page:3024-3034
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

He Lizhen¹²³⁴,Zeng Lilan¹²³⁴,Mai Xiaoxuan¹²³⁴,Shi Changzheng⁵⁶⁷⁴,Luo Liangping⁵⁶⁷⁴,Chen Tianfeng¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Jinan University

3. Guangzhou 510632

4. China

5. Medical Imaging Center

6. The First Affiliated Hospital of Jinan University

7. Guangzhou

Abstract

Herein we design and synthesize a novel selenium-based composite nanosystem that could significantly enhance the cellular uptake in glioma cells through nucleolin mediated endocytosis, and anticancer activity against glioblastoma by inducing cell cycle arrest.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2017/TB/C6TB03365B

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