Surface functionalization of gold nanoclusters with arginine: a trade-off between microtumor uptake and radiotherapy enhancement-Reference-Cited by-同舟云学术

Surface functionalization of gold nanoclusters with arginine: a trade-off between microtumor uptake and radiotherapy enhancement

Published:2020 Issue:13 Volume:12 Page:6959-6963
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Broekgaarden Mans¹²³⁴⁵^ORCID,Bulin Anne-Laure⁶⁷²⁸⁹^ORCID,Porret Estelle¹²³⁴⁵^ORCID,Musnier Benjamin¹²³⁴⁵^ORCID,Chovelon Benoit²¹⁰¹¹⁹¹²,Ravelet Corinne²¹⁰¹¹⁹,Sancey Lucie¹²³⁴⁵^ORCID,Elleaume Hélène⁶⁷²⁸⁹^ORCID,Hainaut Pierre¹²³⁴⁵^ORCID,Coll Jean-Luc¹²³⁴⁵^ORCID,Le Guével Xavier¹²³⁴⁵^ORCID

Affiliation:

1. Institute for Advanced Biosciences

2. Université Grenoble-Alpes

3. INSERM U1209

4. CNRS UMR 5309

5. 38700 La Tronche

6. Synchrotron Radiation for Biomedicine

7. UA 07 INSERM (STROBE)

8. 38043 Grenoble

9. France

10. Département de Pharmacochimie Moléculaire UMR 5063

11. 38400 St Martin d'Hères

12. Institut de Biologie et Pathologie

Abstract

Gold nanoclusters (AuNC) have strong potential for cancer imaging and therapy. We demonstrate that optimizing the surface chemistry of AuNCs for increased tumor uptake can significantly affect its potential to augment radiotherapy outcomes.

Funder

Institut National Du Cancer

Fondation ARC pour la Recherche sur le Cancer

Fondation pour la Recherche Médicale

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/D0NR01138J

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1. Radiotherapy of glioblastoma 15 years after the landmark Stupp’s trial: more controversies than standards?