Rational mechanochemical design of Diels–Alder crosslinked biocompatible hydrogels with enhanced properties

Author:

Bailey Sophia J.1ORCID,Barney Christopher W.234ORCID,Sinha Nairiti J.34,Pangali Sai Venkatesh5,Hawker Craig J.1346ORCID,Helgeson Matthew E.34ORCID,Valentine Megan T.24ORCID,Read de Alaniz Javier1ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA 93106, USA

2. Department of Mechanical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, USA

3. Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, USA

4. Materials Research Laboratory, University of California Santa Barbara, Santa Barbara, CA 93106, USA

5. Center for Structural Molecular Biology, Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA

6. Materials Department, University of California Santa Barbara, Santa Barbara, CA 93106, USA

Abstract

The propensity of Diels–Alder adducts to undergo mechanically induced cycloreversion is related to the failure strength of crosslinked hydrogels. Moreover, we present a new diene that imparts rapid gelation and improved material strength.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrical and Electronic Engineering,Process Chemistry and Technology,Mechanics of Materials,General Materials Science

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