Can 2,2,2-trifluoroethanol be an efficient protein denaturant than methanol and ethanol under thermal stress?
Author:
Affiliation:
1. Molecular Simulation Laboratory
2. Department of Chemistry
3. National Institute of Technology
4. Rourkela – 769008
5. India
Abstract
We report the heterogeneous unfolding phenomenon of a small protein Chymotrypsin Inhibitor 2 in various concentrations of methanol, ethanol and TFE solutions by performing atomistic molecular dynamics simulation studies. Our study reveals that the unfolding phenomenon of CI2 under thermal stress majorly depends on the concentration and the nature of the alcohol.
Funder
Science and Engineering Research Board
National Institute of Technology Rourkela
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2018/CP/C8CP01222A
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