Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides-Reference-Cited by-同舟云学术

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Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides

Published:2018 Issue:3 Volume:9 Page:1410-1423
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Qin Zifei¹²³⁴⁵^ORCID,Li Shishi¹²³⁴,Yao Zhihong¹²³⁴⁵^ORCID,Hong Xiaodan¹²³⁴⁶,Wu Baojian¹²³⁴⁵,Krausz Kristopher W.⁷⁸⁹¹⁰¹¹,Gonzalez Frank J.⁷⁸⁹¹⁰¹¹,Gao Hao¹²³⁴⁵,Yao Xinsheng¹²³⁴⁵^ORCID

Affiliation:

1. College of Pharmacy

2. Jinan University

3. Guangzhou 510632

4. P. R. China

5. Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

6. Guangzhou Research and Creativity Biotechnology Co. Ltd

7. Laboratory of Metabolism

8. Center for Cancer Research

9. National Cancer Institute

10. National Institutes of Health

11. Bethesda

Abstract

We determine the contributions of BCRP and MRP transporters in HeLa cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2018/FO/C7FO01298E

Reference44 articles.

1. An evaluation of the latestin vitrotools for drug metabolism studies

2. Variation in Anastrozole Metabolism and Pharmacodynamics in Women with Early Breast Cancer

3. Cytochromes P450 and metabolism of xenobiotics

4. Regioselective Sulfation and Glucuronidation of Phenolics: Insights into the Structural Basis

5. First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics

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3. Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu-gu-zhi) and its potential inhibition against human cytochrome P450s and UDP-glucuronosyltransferases;Journal of Pharmacy and Pharmacology;2020-08-04

4. Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin-O-glucuronide in HeLa1A1 cells;Journal of Pharmacy and Pharmacology;2020-07-09

5. Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells;Xenobiotica;2020-04-01

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