Bypassing the requirement for aminoacyl-tRNA by a cyclodipeptide synthase enzyme-Reference-Cited by-同舟云学术

Bypassing the requirement for aminoacyl-tRNA by a cyclodipeptide synthase enzyme

Published:2021 Issue:1 Volume:2 Page:230-240
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Harding Christopher J.¹²³⁴⁵^ORCID,Sutherland Emmajay¹²³⁴⁵^ORCID,Hanna Jane G.⁶⁷⁸^ORCID,Houston Douglas R.⁹¹⁰¹¹¹²¹³^ORCID,Czekster Clarissa M.¹²³⁴⁵^ORCID

Affiliation:

1. School of Biology

2. Biomedical Sciences Research Complex

3. University of St Andrews

4. St Andrews

5. Fife KY16 9ST

6. Arab Academy for Science

7. Technology, and Maritime Transport (AASTMT)

8. Egypt

9. Institute of Quantitative Biology

10. Biochemistry and Biotechnology

11. University of Edinburgh

12. Edinburgh

13. UK

Abstract

Cyclodipeptide synthases recognize a minimalistic substrate to produce cyclic dipeptides in a tRNA-independent manner.

Funder

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D0CB00142B

Reference56 articles.

1. A Comprehensive Overview of the Cyclodipeptide Synthase Family Enriched with the Characterization of 32 New Enzymes

2. Analysis of 51 cyclodipeptide synthases reveals the basis for substrate specificity

3. Aminoacyl-tRNA-Utilizing Enzymes in Natural Product Biosynthesis

4. 2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

5. Rational and combinatorial tailoring of bioactive cyclic dipeptides

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