Transition-metal-free α-arylation of nitroketones with diaryliodonium salts for the synthesis of tertiary α-aryl, α-nitro ketones

Author:

An Yang1234,Zhang Xiao-Ming1234ORCID,Li Ze-Yu1234,Xiong Wen-Hui1234,Yu Run-Dong1234,Zhang Fu-Min12345ORCID

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering

2. Lanzhou University

3. Lanzhou 730000

4. P. R. China

5. Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry

Abstract

Transition-metal-free α-arylation of α-nitroketones with diaryliodonium salts has been developed for the first time and applied in the synthesis of tiletamine.

Funder

National Natural Science Foundation of China

Ministry of Education of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference73 articles.

1. The Nitro Group in Organic Synthesis , ed. N. Ono , Wiley-VCH , New York , 2001

2. R. A. Aitken and K. M.Aitken , Nitroalkanes , in Science of Synthesis , ed. K. Banert , Thieme , Stuttgart , 2010 , vol. 41, pp. 9–258

3. Some Aspects of the Chemistry of Nitro Compounds

4. Displacement of the nitro group of substituted nitrobenzenes-a synthetically useful process

5. Nucleophilic Substitution Reactions of Tetrabutylammonium aci-Nitronates with p-Substituted Nitrobenzenes

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