Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy-Reference-Cited by-同舟云学术

Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy

Published:2022 Issue:43 Volume:12 Page:28279-28282
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Hu Jin¹^ORCID,Shi Jianquan²,Yuan Yeshuang³,Li Shengjie¹,Zhang Bo¹,Dong Haitao⁴,Zhong Qing¹,Xie Qiu¹,Bai Xiaoyin⁵,Li Yingxing¹

Affiliation:

1. Department of Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China

2. Department of Intensive Care Unit, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China

3. Department of Rheumatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Clinical Immunology Center, Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China

4. Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China

5. Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China

Abstract

An easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon concatemers with improved pharmaceutical profiles.

Funder

National Natural Science Foundation of China

Peking Union Medical College Hospital

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA04978C

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