Novel anti-HIV-1 NNRTIs based on a pyrazolo[4,3-d]isoxazole backbone scaffold: design, synthesis and insights into the molecular basis of action-Reference-Cited by-同舟云学术

Novel anti-HIV-1 NNRTIs based on a pyrazolo[4,3-d]isoxazole backbone scaffold: design, synthesis and insights into the molecular basis of action

Published:2014 Issue:11 Volume:5 Page:1685-1692
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Gomha Sobhi M.¹²³⁴,Badrey Mohamed G.⁵²⁶⁷,Abdalla Mohamed M.⁸⁹,Arafa Reem K.¹⁰¹¹³¹²

Affiliation:

1. Department of Chemistry

2. Faculty of Science

3. Cairo University

4. Giza, Egypt

5. Chemistry Department

6. Fayoum University

7. El-Fayoum, Egypt

8. Research Unit

9. 6th October City, Egypt

10. Pharmaceutical Chemistry Department

11. Faculty of Pharmacy

12. Cairo, Egypt

Abstract

Design and synthesis of novel anti-HIV-1 NNRTIs based on a pyrazolo[4,3-d]isoxazole backbone scaffold.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00282B

Reference37 articles.

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2. “UNAIDS reports a 52% reduction in new HIV infections among children and a combined 33% reduction among adults and children since 2001”, http://www.unaids.org/en/resources/-presscentre/pressreleaseandstatementarchive/2013/september/20130923prunga/ , Retrieved May 7th, 2014

3. Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach, World Health Organization , 2010 , pp. 19–20 , http://whqlibdoc.who.int/publications/2010/9789241599764_eng.pdf , Retrieved May 7th, 2014

4. Meta-analyses on Pediatric Infections and Vaccines

5. De Clercq, E. "Medmicro Chapter 52", http://intranet.tdmu.edu.te.ua/-data/cd/disk2/ch052.htm , Retrieved May 7th, 2014

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