Lycopene ameliorates islet function and down-regulates the TLR4/MyD88/NF-κB pathway in diabetic mice and Min6 cells-Reference-Cited by-同舟云学术

Lycopene ameliorates islet function and down-regulates the TLR4/MyD88/NF-κB pathway in diabetic mice and Min6 cells

Published:2023 Issue:11 Volume:14 Page:5090-5104
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Liu Yage¹,Tian Yimiao¹,Dai Xuan¹,Liu Tianyuan¹,Zhang Yueyi¹,Wang Shan¹,Shi Hanfen¹,Yin Jiyuan¹,Xu Tianshu¹,Zhu Ruyuan¹,Zhang Yanfei²,Zhao Dandan¹,Gao Sihua¹,Wang Xiang-Dong³,Wang Lili⁴,Zhang Dongwei¹^ORCID

Affiliation:

1. Diabetes Research Center, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

2. Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China

3. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA

4. Department of TCM Pharmacology, Chinese Material Medica School, Beijing University of Chinese Medicine, Beijing 102488, China

Abstract

In diabetic islets, the infiltration of macrophages into the intra-islets triggers islet β cells dysfunction. Lycopene may preserve M1/M2 macrophage homeostasis to improve islet function via the TLR4/MyD88/NF-κB signaling pathway.

Funder

U.S. Department of Agriculture

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO00559C

Reference75 articles.

1. Mitophagy protects β cells from inflammatory damage in diabetes

2. Metabolic cycles and signals for insulin secretion