Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule-Reference-Cited by-同舟云学术

Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule

Published:2024 Issue:4 Volume:15 Page:1402-1408
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Watanabe Kenji¹^ORCID,Mao Qiyue²,Zhang Zhouen¹,Hata Machi²,Kodera Masahito²^ORCID,Kitagishi Hiroaki²^ORCID,Niwa Takashi¹³⁴^ORCID,Hosoya Takamitsu¹⁴^ORCID

Affiliation:

1. Laboratory for Chemical Biology, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan

2. Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan

3. Laboratory for Molecular Transformation Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan

4. Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), Chiyoda-ku, Tokyo 101-0062, Japan

Abstract

2 nm sized gold nanoclusters with azido and amino groups were synthesized. The gold nanoclusters were conjugated with a caged anticancer compound and a photosensitizer for photouncaging, resulting in photoinduced toxicity in cancer cells.

Funder

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Core Research for Evolutional Science and Technology

Research Center for Biomedical Engineering

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC04365G

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