Multivalent nanoparticles for personalized theranostics based on tumor receptor distribution behavior
Author:
Affiliation:
1. Key Laboratory of Functional Polymer Materials of the Ministry of Education
2. Institute of Polymer Chemistry
3. College of Chemistry
4. Nankai University
5. Tianjin 300071
Abstract
The distribution behaviour of folate receptors associated with the receptor overexpression level affects the best matching ligand valency of multivalent nanoparticles.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Tianjin City
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science
Link
http://pubs.rsc.org/en/content/articlepdf/2019/NR/C8NR09347D
Reference59 articles.
1. Antigen-Specific Binding of Multivalent Soluble Antigen Arrays Induces Receptor Clustering and Impedes B Cell Receptor Mediated Signaling
2. Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligand–Receptor Interactions That Tune EphB2 Receptor Clustering
3. Spatial Screening of Hemagglutinin on Influenza A Virus Particles: Sialyl-LacNAc Displays on DNA and PEG Scaffolds Reveal the Requirements for Bivalency Enhanced Interactions with Weak Monovalent Binders
4. Pathogen Inhibition by Multivalent Ligand Architectures
5. Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect
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