Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2′-deoxyzebularine
Author:
Affiliation:
1. School of Fundamental Sciences
2. Massey University
3. Palmerston North 4442
4. New Zealand
5. Maurice Wilkins Centre for Molecular Biodiscovery
Abstract
Selective inhibitors for APOBEC3B and APOBEC3A/G were obtained by substituting the preferred 2′-deoxycytidine by 2′-deoxyzebularine (Z) in a CCC DNA-motif.
Funder
Worldwide Cancer Research
Massey University
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01781J
Reference55 articles.
1. APOBECs and virus restriction
2. Evolution of the AID/APOBEC Family of Polynucleotide (Deoxy)cytidine Deaminases
3. Retroviral restriction by APOBEC proteins
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5. Cytidine Deaminases as a Weapon Against Retroviruses and a New Target for Antiviral Therapy
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