Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)-Reference-Cited by-同舟云学术

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Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)

Published:2016 Issue:25 Volume:14 Page:5922-5927
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Martin Rainer E.¹²³⁴⁵,Lehmann Johannes¹²³⁴⁵,Alzieu Thibaut¹²³⁴⁵,Lenz Mario¹²³⁴⁵,Carnero Corrales Marjorie A.¹²³⁴⁵^ORCID,Aebi Johannes D.¹²³⁴⁵,Märki Hans Peter¹²³⁴⁵,Kuhn Bernd¹²³⁴⁵,Amrein Kurt⁶⁷³⁴⁵,Mayweg Alexander V.¹²³⁴⁵,Britton Robert⁸⁹¹⁰¹¹¹²

Affiliation:

1. Medicinal Chemistry

2. Roche Pharmaceutical Research and Early Development (pRED)

3. Roche Innovation Center Basel

4. F. Hoffmann-La Roche Ltd

5. CH-4070 Basel

6. Discovery Infectious Disease

7. Roche Pharma Research and Early Development (pRED)

8. Department of Chemistry

9. Simon Fraser University

10. 8888 University Drive

11. Burnaby

12. Canada

Abstract

A series of potent and selective aldosterone synthase (CYP11B2) inhibitors were prepared in one step through an intermolecular Kondrat'eva reaction.

Funder

Michael Smith Foundation for Health Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00848H

Reference46 articles.

1. Renin–Angiotensin System Blockade and Cardiovascular and Renal Protection

2. Novel RAAS agonists and antagonists: clinical applications and controversies

3. The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

4. Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

5. Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial

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1. Emerging trends in small molecule inhibitors targeting aldosterone synthase: A new paradigm in cardiovascular disease treatment;European Journal of Medicinal Chemistry;2024-08

2. Identification of sulfonylpyrimidines as novel selective aldosterone synthase (CYP11B2) inhibitors;Bioorganic & Medicinal Chemistry;2024-06

3. Synthesis, structural and X-ray analysis evaluations and computational studies of newly tetrahydroisoquinoline derivatives as potent against microsomal prostaglandin E synthase 1;Journal of Biomolecular Structure and Dynamics;2023-10-25

4. Development and application of decatungstate catalyzed C–H ¹⁸F- and ¹⁹F-fluorination, fluoroalkylation and beyond;Chemical Science;2023

5. Sources, Transformations, Syntheses, and Bioactivities of Monoterpene Pyridine Alkaloids and Cyclopenta[c]pyridine Derivatives;Molecules;2022-10-24

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