Design of self-assembling anti-epileptic drug for long-acting drug delivery <i>in vivo</i>-Reference-Cited by-同舟云学术

Design of self-assembling anti-epileptic drug for long-acting drug delivery in vivo

Published:2022 Issue:21 Volume:10 Page:6307-6314
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Ikeda Yutaka¹,Tajika Yuya¹,Nagasaki Yukio¹²³^ORCID

Affiliation:

1. Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan

2. Master's School of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan

3. Center for Research in Isotopes and Environmental Dynamics (CRiED), University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan

Abstract

Self-assembling polymer micelle (NanoVPA) composed of PEG-b-poly(vinyl valproate) was developed. IP administration of NanoVPA extended the bioavailability of VPA, which increased its therapeutic effect against epilepsy, reducing its adverse effects.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM01064J

Reference20 articles.

1. Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences

2. A systematic review of population pharmacokinetics of valproic acid

3. Valproic Acid Overdose Review of a Case With Electrocardiographic Changes

4. Oral valproic acid for epilepsy - long-term experience in therapy and side effects

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Epilepsy Treatment and Diagnosis Enhanced by Current Nanomaterial Innovations: A Comprehensive Review;Molecular Neurobiology;2024-06-29

2. Self-assembling polymer-based short chain fatty acid prodrugs ameliorate non-alcoholic steatohepatitis and liver fibrosis;Biomaterials;2023-04