A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides-Reference-Cited by-同舟云学术

A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides

Published:2014 Issue:2 Volume:31 Page:154-159
ISSN:0265-0568
Container-title:Nat. Prod. Rep.
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Reimer Daniela¹²³⁴,Bode Helge B.¹²³⁴

Affiliation:

1. Merck Stiftungsprofessur für Molekulare Biotechnologie

2. Fachbereich Biowissenschaften

3. Goethe Universität Frankfurt

4. 60438 Frankfurt am Main, Germany

Abstract

ThisHighlightdescribes the recently discovered prodrug activation mechanism found in the biosynthesis of nonribosomally produced peptides and peptide/polyketide hybrids as well as related mechanisms.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/NP/C3NP70081J

Reference41 articles.

1. Polyketide biosynthesis: a millennium review

2. Nonribosomal peptide synthetases: structures and dynamics

3. Molecular Mechanisms Underlying Nonribosomal Peptide Synthesis: Approaches to New Antibiotics

4. Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis

5. The Biosynthetic Logic of Polyketide Diversity

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