Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing-Reference-Cited by-同舟云学术

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Published:2019 Issue:2 Volume:6 Page:385-393
ISSN:2051-6347
Container-title:Materials Horizons
language:en
Short-container-title:Mater. Horiz.

Author:

Liu Zehua¹²³⁴⁵,Li Yunzhan⁶⁷⁸⁹¹⁰,Li Wei¹²³⁴⁵,Lian Wenhua⁶⁷⁸⁹¹⁰,Kemell Marianna¹¹⁴⁵¹²^ORCID,Hietala Sami¹¹⁴⁵¹²^ORCID,Figueiredo Patrícia¹²³⁴⁵,Li Li⁶⁷⁸⁹¹⁰,Mäkilä Ermei¹³¹⁴¹⁵¹⁶¹²,Ma Ming¹⁷¹⁸¹⁹²⁰^ORCID,Salonen Jarno¹³¹⁴¹⁵¹⁶¹²,Hirvonen Jouni T.¹²³⁴⁵,Liu Dongfei¹²³⁴⁵^ORCID,Zhang Hongbo²¹²²¹⁶¹²²³,Deng Xianming⁶⁷⁸⁹¹⁰,Santos Hélder A.¹²³⁴⁵^ORCID

Affiliation:

1. Drug Research Program

2. Division of Pharmaceutical Chemistry and Technology

3. Faculty of Pharmacy

4. University of Helsinki

5. Helsinki

6. State Key Laboratory of Cellular Stress Biology

7. Innovation Center for Cell Signaling Network

8. School of Life Sciences

9. Xiamen University

10. Fujian

11. Department of Chemistry

12. Finland

13. Laboratory of Industrial Physics

14. Department of Physics

15. University of Turku

16. Turku

17. State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics

18. Chinese Academy of Sciences

19. Shanghai 200050

20. China

21. Department of Pharmaceutical Science

22. Åbo Akademi University

23. Turku Center of Biotechnology

Abstract

A self-regulated dynamic nanohybrid that can sensitively respond to hyperglycemic microenvironment is developed. The nanohybrid with a core/shell structure is produced through a single-step microfluidics nanoprecipitation method, where drugs-loaded porous silicon (PSi) nanoparticles are encapsulated by H₂O₂ responsive polymeric matrix.

Funder

Ministry of Science and Technology of the People's Republic of China

H2020 European Research Council

Suomen Akatemia

National Natural Science Foundation of China

China Scholarship Council

Orionin Tutkimussäätiö

Jane ja Aatos Erkon Säätiö

Sigrid Juséliuksen Säätiö

Helsingin Yliopisto

Publisher

Royal Society of Chemistry (RSC)