Application of the combination of ball-milling and hot-melt extrusion in the development of an amorphous solid dispersion of a poorly water-soluble drug with high melting point
Author:
Affiliation:
1. Laboratory of Pharmaceutical Engineering
2. College of Pharmacy
3. Nanjing University of Chinese Medicine
4. Nanjing 210023
5. China
Abstract
The aim of the study was to develop an amorphous solid dispersion of a poorly water-soluble drug with high melting point by ball milling and hot melt extrusion as a co-processing method.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA00810A
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1. An approach for chemical stability during melt extrusion of a drug substance with a high melting point
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