Stealthy nanoparticles protect endothelial barrier from leakiness by resisting the absorption of VE-cadherin-Reference-Cited by-同舟云学术

Stealthy nanoparticles protect endothelial barrier from leakiness by resisting the absorption of VE-cadherin

Published:2021 Issue:29 Volume:13 Page:12577-12586
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Huang Yuan¹,Wang Suxiao¹^ORCID,Zhang Jinzhi¹,Wang Hangxing¹^ORCID,Zou Qichao¹,Wu Limin²

Affiliation:

1. Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, China

2. Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China

Abstract

The design of a series of NPs with or without ultralow protein corona property are described and the ultralow protein corona NPs can penetrate the endothelial cell junction without phosphorylating the residues on VE-cad, thus, avoid NanoEL effect.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D1NR03155D

Reference39 articles.

1. Cells in focus: endothelial cell

2. Endothelial cell–cell junctions: happy together

3. ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters