Hybrid molecules based on an emodin scaffold. Synthesis and activity against SARS-CoV-2 and <i>Plasmodium</i>-Reference-Cited by-同舟云学术

Hybrid molecules based on an emodin scaffold. Synthesis and activity against SARS-CoV-2 and Plasmodium

Published:2023 Issue:36 Volume:21 Page:7382-7394
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Li Youzhi¹²³,Touret Franck⁴,de Lamballerie Xavier⁴,Nguyen Michel²³,Laurent Marion²³,Benoit-Vical Françoise²³,Robert Anne²³^ORCID,Liu Yan¹^ORCID,Meunier Bernard¹²³

Affiliation:

1. Education Mega Center, Guangdong University of Technology, School of Chemical Engineering and Light Industry, No. 100 Waihuan Xi Road, Guangzhou, P. R. China

2. Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France

3. New Antimalarial Molecules and Pharmacological Approaches, MAAP, Inserm ERL 1289, 205 Route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France

4. Unité des Virus Émergents (UVE), Aix Marseille Univ, IRD 190, Inserm 1207, 27 Boulevard Jean Moulin, 13005 Marseille Cedex 05, France

Abstract

A series of hybrid emodin–polyamine or emodin–norchlorcyclizine molecules have been synthesized and evaluated as potential antiviral and antimalarial agents. (R)-Emoxyzine-2 was as potent as remdesivir in inhibiting SARS-CoV-2 replication.

Funder

Institut National de la Santé et de la Recherche Médicale

Centre National de la Recherche Scientifique

Department of Education of Guangdong Province

Guangdong University of Technology

Fondation pour la Recherche Médicale

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01122D