Ratiometric co-delivery of doxorubicin and docetaxel by covalently conjugating with mPEG-poly(β-malic acid) for enhanced synergistic breast tumor therapy-Reference-Cited by-同舟云学术

Ratiometric co-delivery of doxorubicin and docetaxel by covalently conjugating with mPEG-poly(β-malic acid) for enhanced synergistic breast tumor therapy

Published:2020 Issue:46 Volume:11 Page:7330-7339
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Yu Zhe¹²³⁴⁵,Li Hua⁶²³⁴⁵^ORCID,Jia Yiyang⁷⁸⁹¹⁰⁵,Qiao Youbei¹²³⁴⁵,Wang Chaoli¹²³⁴⁵,Zhou Qing¹¹²³⁴⁵,He Xin¹²³⁴⁵,Yu Shibin¹²¹³³⁴⁵,Yang Tiehong¹²³⁴⁵,Wu Hong¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry and Pharmaceutical Analysis

2. School of Pharmacy

3. Air Force Medical University

4. Xi'an 710032

5. China

6. Department of Chinese Materia Medica and Natural Medicines

7. Department of Pharmacology

8. Jinling Hospital

9. Medical School of Nanjing University

10. Nanjing 210002

11. Department of Pharmaceutics

12. State Key Laboratory of Military Stomatology

13. School of Stomatology

Abstract

Ratiometric codelivery of doxorubicin and docetaxel through an engineered nanoconjugate based on mPEG-PMLA facilitates the accumulation of drugs at the tumor site and enhances synergistic antitumor response.

Funder

National Natural Science Foundation of China

Science and Technology Innovation as a Whole Plan Projects of Shaanxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/PY/D0PY01130D

Reference47 articles.

1. Cancer statistics, 2020

2. Nanotechnology for Multimodal Synergistic Cancer Therapy