Limonin alleviates high-fat diet-induced dyslipidemia by regulating the intestinal barrier <i>via</i> the microbiota-related ILC3–IL22

Limonin alleviates high-fat diet-induced dyslipidemia by regulating the intestinal barrier via the microbiota-related ILC3–IL22–IL22R pathway

Published:2024 Issue:5 Volume:15 Page:2679-2692
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Wu Wangling¹^ORCID,Pan Yingying¹,Zheng Tianyan¹,Sun Haoyi¹,Li Xia¹,Zhu Haiyan¹,Wang Zheng¹,Zhou Xin¹

Affiliation:

1. School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China

Abstract

Limonin supplementation can activate the microbiota-associated ILC3–IL22–IL22R pathway to promote pSTAT3 in intestinal epithelial cells, thereby enhancing the impaired intestinal barrier, down-regulating the expression of key lipid transporters, and ultimately improving HFD-induced dyslipidemia.

Funder

Key Research and Development Program of Sichuan Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO04530G

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