Green synthesis of fluorescent carbon nanodots from sage leaves for selective anticancer activity on 2D liver cancer cells and 3D multicellular tumor spheroids

Author:

Sawalha Shadi1ORCID,Abdallah Samer2ORCID,Barham Amal1,Badawi Hala1,Barham Zeina1,Ghareeb Ahmad3,Misia Giuseppe4,Collavini Silvia5,Silvestri Alessandro6,Prato Maurizio45ORCID,Assali Mohyeddin3ORCID

Affiliation:

1. Chemical Engineering Program, Faculty of Engineering and Information Technology, An-Najah National University, P.O. Box 7, Nablus, Palestine

2. Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine

3. Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, Palestine

4. Department of Chemical and Pharmaceutical Sciences INSTM UdR Trieste, University of Trieste, via Licio Giorgieri 1, 34127 Trieste, Italy

5. Center for Cooperative Research in Biomaterials (CIC BiomaGUNE), Basque Research and Technology Alliance (BRTA), Donostia-San Sebastián 20014, Spain

6. Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Venezia 30170, Italy

Abstract

Green synthesis of carbon nanodots (CNDs) from sage leaves has been achieved using a hydrothermal technique. The synthesized CNDs demonstrated selective anticancer activity against hepatocellular carcinoma and hindered the formation of 3D spheroids.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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