Biosynthesis of the bacterial antibiotic 3,7-dihydroxytropolone through enzymatic salvaging of catabolic shunt products-Reference-Cited by-同舟云学术

Biosynthesis of the bacterial antibiotic 3,7-dihydroxytropolone through enzymatic salvaging of catabolic shunt products

Published:2024 Issue:20 Volume:15 Page:7749-7756
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Höing Lars¹,Sowa Sven T.¹,Toplak Marina²,Reinhardt Jakob K.¹^ORCID,Jakob Roman³,Maier Timm³^ORCID,Lill Markus A.⁴,Teufel Robin¹^ORCID

Affiliation:

1. Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland

2. Hilde-Mangold-Haus (CIBSS), University of Freiburg, Habsburgerstrasse 49, 79104 Freiburg im Breisgau, Germany

3. Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland

4. Computational Pharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland

Abstract

The biosynthesis of the bacterial antibiotic dihydroxytropolone was reconstituted in vitro starting from a catabolic shunt product. The involved key flavoprotein monooxygenase TrlE was further structurally and mechanistically characterized.

Funder

Deutsche Forschungsgemeinschaft

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC01715C

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