Fluorescent annulated imidazo[4,5-<i>c</i>]isoquinolines <i>via</i> a GBB-3CR/imidoylation sequence – DNA-interactions in pUC-19 gel electrophoresis mobility shift assay-Reference-Cited by-同舟云学术

Fluorescent annulated imidazo[4,5-c]isoquinolines via a GBB-3CR/imidoylation sequence – DNA-interactions in pUC-19 gel electrophoresis mobility shift assay

Published:2022 Issue:17 Volume:20 Page:3598-3604
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Stahlberger M.¹^ORCID,Steinlein O.²,Adam C. R.¹,Rotter M.¹,Hohmann J.¹,Nieger M.³,Köberle B.²,Bräse S.¹⁴^ORCID

Affiliation:

1. Institute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany

2. Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20, 76131 Karlsruhe, Germany

3. Department of Chemistry, University of Helsinki, P.O. Box 55 (A. I. Virtasen aukio 1), 00014, Finland

4. Institute of Biological and Chemical Systems – IBCS-FMS, Karlsruhe Institute of Technology (KIT), Herman-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

Abstract

Modular, sequential synthetic route involving a GBB-3CR and an imidoylative Hartwig–Buchwald amination towards fluorescent polyheterocycles. Investigation of DNA-interactions in a pUC-plasmid electrophoresis mobility shift assay.

Funder

Karlsruhe Institute of Technology

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00372D

Reference57 articles.

1. Multicomponent Reactions with Isocyanides

2. Chemistry and Biology Of Multicomponent Reactions