Affiliation:
1. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Abstract
RNA self-copying using an activated adenosine substrate is challenging. Our structure studies reveal the binding motifs of adenosine substrates. The obtained structures explain the disfavorable conformations for nucleophilic reactions.
Funder
Argonne National Laboratory
U.S. Department of Energy
Michigan Economic Development Corporation
Michigan Technology Tri-Corridor
Publisher
Royal Society of Chemistry (RSC)
Subject
Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)