Binding affinity-based intracellular drug detection enabled by a unimolecular cucurbit[7]uril-dye conjugate-Reference-Cited by-同舟云学术

Binding affinity-based intracellular drug detection enabled by a unimolecular cucurbit[7]uril-dye conjugate

Published:2023 Issue:10 Volume:4 Page:760-764
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Liu Yanxi¹²,Hu Changming³,Serna Julian A.¹,Biedermann Frank³^ORCID,Levkin Pavel A.¹⁴^ORCID

Affiliation:

1. Karlsruhe Institute of Technology (KIT), Institute of Biological and Chemical Systems – Functional Molecular Systems (IBCS-FMS), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen 76344, Germany

2. Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing 400038, China

3. Karlsruhe Institute of Technology (KIT), Institute of Nanotechnology (INT), Hermann-von-Helmholtz Platz 1, Eggenstein-Leopoldshafen 76344, Germany

4. Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry (IOC), Kaiserstraße 12, Karlsruhe 76131, Germany

Abstract

We demonstrate an application of macrocyclic cucurbit[7]uril (CB7) host covalently coupled to a nitrobenzoxadiazole (NBD) fluorescent dye (CB7-NBD conjugate) as a sensor for detecting diverse analytes in the intracellular compartment of live cells.

Funder

Helmholtz-Gemeinschaft

Chongqing Postdoctoral Science Foundation

Deutsche Forschungsgemeinschaft

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00131H

Reference32 articles.