Heavy element incorporation in nitroimidazole radiosensitizers: molecular-level insights into fragmentation dynamics

Author:

Svensson Pamela H. W.1ORCID,Schwob Lucas2,Grånäs Oscar1ORCID,Unger Isaak1,Björneholm Olle1,Timneanu Nicusor1ORCID,Lindblad Rebecka1,Vieli Anna-Lydia1,Zamudio-Bayer Vicente3ORCID,Timm Martin3,Hirsch Konstantin3ORCID,Caleman Carl14ORCID,Berholts Marta5ORCID

Affiliation:

1. Department of Physics and Astronomy, University of Uppsala, SE-75120 Uppsala, Sweden

2. Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607 Hamburg, Germany

3. Abteilung für Hochempfindliche Röntgenspektroskopie, Helmholtz Zentrum Berlin für Materialien und Energie, 12489 Berlin-Adlershof, Germany

4. Center for Free-Electron Laser Science, DESY, DE-22607 Hamburg, Germany

5. Institute of Physics, University of Tartu, W. Ostwald 1, EST-50411, Tartu, Estonia

Abstract

The present study investigates the photofragmentation behavior of iodine-enhanced nitroimidazole-based radiosensitizer model compounds in their protonated form using near-edge X-ray absorption mass spectrometry and quantum mechanical calculations.

Funder

Helmholtz-Gemeinschaft

Eesti Teadusagentuur

Vetenskapsrådet

European Cooperation in Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

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