Design, synthesis and antimycobacterial activity of imidazo[1,5-a]quinolines and their zinc-complexes

Author:

Marner Michael1ORCID,Kulhanek Niclas2,Eichberg Johanna13,Hardes Kornelia13,Molin Michael Dal45,Rybniker Jan456,Kirchner Michael2,Schäberle Till F.178ORCID,Göttlich Richard2ORCID

Affiliation:

1. Fraunhofer-Institute for Molecular Biology and Applied Ecology (IME) Branch Bioresources, Ohlebergsweg 12, 35392 Giessen, Germany

2. Institute of Organic Chemistry, Justus-Liebig-University, Heinrich-Buff-Ring 17, Giessen 35392, Germany

3. BMBF Junior Research Group in Infection Research “ASCRIBE”, Branch for Bioresources of the Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Ohlebergsweg 12, 35392 Giessen, Germany

4. Department I of Internal Medicine, University of Cologne, 50937 Cologne, Germany

5. Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany

6. German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany

7. Institute for Insect Biotechnology, Justus-Liebig-University Giessen, Ohlebergsweg 12, 35392, Giessen, Germany

8. German Center for Infection Research (DZIF), Partner Site Giessen-Marburg-Langen, Ohlebergsweg 12, 35392 Giessen, Germany

Abstract

In this study, we report the novel bioactivity of imidazo[1,5-a]quinolines and their complexes against Mycobacterium tuberculosis Mtb.

Publisher

Royal Society of Chemistry (RSC)

Reference27 articles.

1. T. M.Daniel , J. H.Bates and K. A.Downes , in Tuberculosis , ed. B. R. Bloom , ASM Press, Washington, D. C , 1994 , pp. 13–24

2. Epidemiology: A mortal foe

3. World Health Organization , Global Tuberculosis Report 2023 , WHO , Geneva , 2023 , https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2023 , (accessed 19 February 2024)

4. World Health Organization , Global Tuberculosis Report 2022 , WHO , Geneva , 2022 , https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022 , (accessed 9 October 2023)

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