Vanadium(v) complexes derived from triphenylphosphonium and hydrazides: cytotoxicity evaluation and interaction with biomolecules

Author:

Martins Francisco Mainardi1ORCID,Iglesias Bernardo Almeida2ORCID,Chaves Otávio Augusto34ORCID,Gutknecht da Silva Jean Lucas5ORCID,Leal Daniela Bitencourt Rosa5ORCID,Back Davi Fernando1ORCID

Affiliation:

1. Laboratory of Inorganic Materials, Department of Chemistry, CCNE, UFSM, Santa Maria, RS, 97105-900, Brazil

2. Laboratory of Bioinorganic and Porphyrin Materials, Department of Chemistry, CCNE, UFSM, Santa Maria, RS, 97105-900, Brazil

3. CQC-IMS, Department of Chemistry, University of Coimbra, Rua Larga s/n, Coimbra, 3004-535, Portugal

4. Laboratory of Immunopharmacology, Centro de Pesquisa, Inovação e Vigilância em COVID-19 e Emergências Sanitárias (CPIV), Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, 21040-361, Brazil

5. Laboratory of Experimental and applied immunobiology, CCNE, Santa Maria, RS, 97105-900, Brazil

Abstract

This work presents the synthesis, characterization, interactions, and cytotoxicity of dioxidovanadium(v) complexes (C1–C5) with a triphenylphosphonium moiety.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

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