Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid – a CF3O-containing analogue of natural lipophilic amino acids

Author:

Kondratov Ivan S.12345,Logvinenko Ivan G.12345,Tolmachova Nataliya A.12345,Morev Roman N.123,Kliachyna Maria A.123,Clausen Florian6789,Daniliuc Constantin G.6789,Haufe Günter678910ORCID

Affiliation:

1. Enamine Ltd

2. Kyiv

3. Ukraine

4. Institute of Bioorganic Chemistry and Petrochemistry

5. National Academy of Sciences of Ukraine

6. Organisch-Chemisches Institut

7. Universität Münster

8. Münster 48149

9. Germany

10. Cells-in-Motion Cluster of Excellence

Abstract

The new enantiopure CF3O-homoserines might be promising surrogates of natural α-amino acids.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference83 articles.

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2. Fluorine and Health. Molecular Imaging, Biomedical Materials and Pharmaceuticals, ed. A. Tressaud and G. Haufe, Elsevier, Amsterdam, 2008, pp. 553–778

3. Fluorine in Medicinal Chemistry and Chemical Biology, ed. I. Ojima, Wiley-Blackwell, 2009, pp. 3–198

4. Fluorine in Pharmaceutical and Medicinal Chemistry. From Biophysical Aspects to Clinical Application, ed. V. Gouverneur and K. Müller, Imperial College Press, London, 2012, pp. 139–331

5. Synthetic strategies to α-trifluoromethyl and α-difluoromethyl substituted α-amino acids

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