Studies of 4-arylthiazolylhydrazones derived from 1-indanones as Trypanosoma cruzi squalene epoxidase inhibitors by molecular simulations-Reference-Cited by-同舟云学术

Studies of 4-arylthiazolylhydrazones derived from 1-indanones as Trypanosoma cruzi squalene epoxidase inhibitors by molecular simulations

Author:

Noguera Guido J.¹²³⁴⁵,Fabian Lucas E.⁶⁷⁵⁸⁹,Lombardo Elisa¹¹⁰¹¹¹²⁸,Finkielsztein Liliana M.¹²³⁴⁵^ORCID

Affiliation:

1. Universidad de Buenos Aires

2. Facultad de Farmacia y Bioquímica

3. Departamento de Farmacología

4. Cátedra de Química Medicinal

5. Junín 956

6. CONICET-Universidad de Buenos Aires

7. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA)

8. Ciudad Autónoma de Buenos Aires

9. Argentina

10. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica

11. Pabellón II

12. Ciudad Universitaria

Abstract

We present for the first time a study at the molecular level of the T. cruzi SE and the structural requirements for its inhibition.

Funder

Consejo Nacional de Investigaciones Científicas y Técnicas

Universidad de Buenos Aires

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

Reference37 articles.

2. http://www.who.int/chagas/

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