G-Quadruplex formation using fluorescent oligonucleotides as a detection method for discriminating AGG trinucleotide repeats-Reference-Cited by-同舟云学术

G-Quadruplex formation using fluorescent oligonucleotides as a detection method for discriminating AGG trinucleotide repeats

Published:2016 Issue:86 Volume:52 Page:12757-12760
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Park Yoojin¹²³⁴⁵,Kim Ki Tae¹²³⁴⁵,Kim Byeang Hyean¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Division of Advanced Materials Science

3. Pohang University of Science and Technology (POSTEH)

4. Pohang 37673

5. Republic of Korea

Abstract

A fluorescent oligonucleotide probe induces the formation of intermolecular G-quadruplexes with AGG trinucleotide repeats. The probe also exhibits 35.0- and 44.7-fold enhanced fluorescence signals for DNA AGG and RNA agg repeat oligonucleotides with respect to the low background signal.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC06566J

Reference32 articles.

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4. Triplet repeats in transcripts: structural insights into RNA toxicity

5. Intramolecular Higher Order Packing of Parallel Quadruplexes Comprising a G:G:G:G Tetrad and a G(:A):G(:A):G(:A):G Heptad of GGA Triplet Repeat DNA

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