Synthesis and preliminary evaluation of octreotate conjugates of bioactive synthetic amatoxins for targeting somatostatin receptor (sstr2) expressing cells-Reference-Cited by-同舟云学术

Synthesis and preliminary evaluation of octreotate conjugates of bioactive synthetic amatoxins for targeting somatostatin receptor (sstr2) expressing cells

Published:2022 Issue:1 Volume:3 Page:69-78
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Pryyma Alla¹^ORCID,Matinkhoo Kaveh¹,Bu Yong Jia¹,Merkens Helen²,Zhang Zhengxing²,Bénard Francois²,Perrin David M.¹^ORCID

Affiliation:

1. Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T 1Z1, Canada

2. Department of Molecular Oncology, BC Cancer, Vancouver, BC, V5Z 1L3, Canada

Abstract

Synthetic amanitin is conjugated to octreotate as a targeting agent: three different linkers and two sites of attachment highlight a robust chemical approach leading to targeted cytotoxicity.

Funder

Canadian Institutes of Health Research

Canadian Cancer Society Research Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D1CB00036E

Reference85 articles.

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