A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer's disease-Reference-Cited by-同舟云学术

A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer's disease

Published:2019 Issue:70 Volume:55 Page:10424-10427
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Lim Hye Rim¹²³⁴,Kim Seo Yun¹²³⁴,Jeon Eun Hee¹²³⁴,Kim Yun Lan¹²³⁴,Shin Yu Mi¹²³⁴,Koo Tae-Sung¹²³⁴,Park Sung Jean⁵⁶⁷⁴,Hong Ki Bum⁸⁹¹⁰⁴,Choi Sungwook¹²³⁴^ORCID

Affiliation:

1. Graduate School of New Drug Discovery and Development

2. Chungnam National University

3. Daejon

4. Republic of Korea

5. College of Pharmacy and Gachon Institute of Pharmaceutical Sciences

6. Gachon University

7. Incheon 406-799

8. New Drug Development Center (NDDC)

9. Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)

10. Daegu 701-310

Abstract

A robust and simple fluorescent assay for the quantification of TTR in human plasma was developed by utilizing an indole-based fluorophore.

Funder

Ministry of Education, Science and Technology

Ministry of Science, ICT and Future Planning

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC04172A

Reference37 articles.

1. Alzheimer's Disease: The Amyloid Cascade Hypothesis

2. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

3. The secretases: enzymes with therapeutic potential in Alzheimer disease

4. Clearance systems in the brain—implications for Alzheimer disease

5. Native State Kinetic Stabilization as a Strategy To Ameliorate Protein Misfolding Diseases: A Focus on the Transthyretin Amyloidoses

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