Dietary choline metabolite TMAO impairs cognitive function and induces hippocampal synaptic plasticity declining through the mTOR/P70S6K/4EBP1 pathway-Reference-Cited by-同舟云学术

Dietary choline metabolite TMAO impairs cognitive function and induces hippocampal synaptic plasticity declining through the mTOR/P70S6K/4EBP1 pathway

Published:2023 Issue:6 Volume:14 Page:2881-2895
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Zhou Shihan¹²^ORCID,Liu Jing¹²,Sun Yan¹²,Xu Ping¹²,Liu Jin ling¹²,Sun Suping¹²,Zhu Boran¹²,Wu Haoxin¹²

Affiliation:

1. College of Traditional Chinese Medicine and College of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China

2. Key Laboratory of Integrative Biomedicine for Brain Diseases, College of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China

Abstract

Choline metabolite trimethylamine-oxide (TMAO) can cause cognitive impairments with neuron loss, damage of synapses and synaptic plasticity by repressing mTOR signalling.

Funder

Graduate Research and Innovation Projects of Jiangsu Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO03874A

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