Acid-sensitive stable polymeric micelle-based oxidative stress nanoamplifier as immunostimulating anticancer nanomedicine

Author:

Kwon Gayoung1,Baek Jinsu2ORCID,Kim Nuri1,Kwon Soonyoung1,Song Nanhee1ORCID,Park Seong-Cheol3,Kim Byeong-Su2ORCID,Lee Dongwon14ORCID

Affiliation:

1. Department of Bionanotechnology and Bioconvergence Engineering, Jeonbuk National University, Jeonju, Jeonbuk 54896, Korea

2. Department of Chemistry, Yonsei University, Seoul, 03722, Korea

3. Department of Polymer Engineering, Sunchon National University, Chonnam 57922, Korea

4. Department of Polymer Nano Science and Technology, Jeonbuk National University, Jeonju, Jeonbuk 54896, Korea

Abstract

Oxidative stress amplifying compounds that not only generate reactive oxygen species (ROS) but also deplete antioxidants could elicit selective killing of cancer cells with minimal toxicity to normal cells and also induce immunogenic cell death (ICD).

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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