Insights from computational analysis: how does the SARS-CoV-2 Delta (B.1.617.2) variant hijack ACE2 more effectively?-Reference-Cited by-同舟云学术

Insights from computational analysis: how does the SARS-CoV-2 Delta (B.1.617.2) variant hijack ACE2 more effectively?

Published:2022 Issue:15 Volume:24 Page:8683-8694
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Xiong Danyang¹,Zhao Xiaoyu¹,Luo Song¹,Duan Lili¹^ORCID

Affiliation:

1. School of Physics and Electronics, Shandong Normal University, Jinan, 250014, China

Abstract

The Delta variant could enhance the electrostatic interaction with ACE2 by introducing two positively charged residues. And under the dominance of T478K mutation, RBM’s loops have a tighter conformation to enhance the grasp effect on the ACE2.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP00843B

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