Constructing chiral aza-quaternary carbon centers by enantioselective carbonylative Heck reaction of o-iodoanilines with allenes-Reference-Cited by-同舟云学术

Constructing chiral aza-quaternary carbon centers by enantioselective carbonylative Heck reaction of o-iodoanilines with allenes

Published:2021 Issue:6 Volume:8 Page:1163-1169
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xu Zhengshuai¹²³⁴⁵,Shen Chaoren¹²³⁴⁵^ORCID,Zhang Hongru¹²³⁴⁵,Wang Peng¹²³⁴⁵,Dong Kaiwu¹²³⁴⁵^ORCID

Affiliation:

1. Chang-Kung Chuang Institute

2. Shanghai Key Laboratory of Green Chemistry and Chemical Process

3. School of Chemistry and Molecular Engineering

4. East China Normal University

5. Shanghai 200241

Abstract

The construction of chiral aza-quaternary C-centers via C–N bond formation is achieved by a Pd-catalysed asymmetric carbonylative Heck reaction of o-iodoanilines with allenes, providing chiral dihydroquinolinone derivatives with moderate to high yield and enantiomeric ratio.

Funder

National Natural Science Foundation of China

East China Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D0QO01486A

Reference63 articles.

1. Contiguous stereogenic quaternary carbons: A daunting challenge in natural products synthesis

2. Enantioselective Catalytic Formation of Quaternary Stereogenic Centers