Injectable colloidal hydrogel with mesoporous silica nanoparticles for sustained co-release of microRNA-222 and aspirin to achieve innervated bone regeneration in rat mandibular defects-Reference-Cited by-同舟云学术

Injectable colloidal hydrogel with mesoporous silica nanoparticles for sustained co-release of microRNA-222 and aspirin to achieve innervated bone regeneration in rat mandibular defects

Published:2019 Issue:16 Volume:7 Page:2722-2735
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Lei Lei¹²³⁴⁵^ORCID,Liu Zhongning¹²³⁴⁵,Yuan Pingyun⁶⁷⁸⁹¹⁰,Jin Ronghua⁶⁷⁸⁹¹⁰,Wang Xiangdong⁶⁷⁸⁹¹⁰,Jiang Ting¹²³⁴⁵^ORCID,Chen Xin⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Department of Prosthodontics

2. Peking University School and Hospital of Stomatology

3. National Clinical Research Center for Oral Diseases

4. National Engineering Laboratory for Digital and Material Technology of Stomatology

5. Beijing Key Laboratory of Digital Stomatology

6. School of Chemical Engineering and Technology

7. Shaanxi Key Laboratory of Energy Chemical Process Intensification

8. Institute of Polymer Science in Chemical Engineering

9. Xi’an Jiao Tong University

10. Xi’an 710049

Abstract

An injectable hydrogel was developed using mesoporous silica nanoparticles to co-deliver miR222 and aspirin, osteogenesis was enhanced by stimulating innervation.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2019/TB/C9TB00025A

Reference81 articles.

1. Evidence for a dense and intimate innervation of the bone tissue, including glutamate-containing fibers

2. Progressive Hemiosteoporosis on the Paretic Side and Increased Bone Mineral Density in the Nonparetic Arm the First Year after Severe Stroke

3. Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration

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