Targeting Brd4 for cancer therapy: inhibitors and degraders-Reference-Cited by-同舟云学术

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Targeting Brd4 for cancer therapy: inhibitors and degraders

Published:2018 Issue:11 Volume:9 Page:1779-1802
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Duan Yingchao¹²³⁴,Guan Yuanyuan¹²³⁴,Qin Wenping¹²³⁴,Zhai Xiaoyu¹²³⁴,Yu Bin⁵⁶⁷⁸⁹^ORCID,Liu Hongmin⁵⁶⁷⁸⁹^ORCID

Affiliation:

1. School of Pharmacy

2. Xinxiang Medical University

3. Xinxiang

4. China

5. Key Laboratory of Advanced Pharmaceutical Technology

6. Ministry of Education of China

7. Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety

8. Institute of Drug Discovery and Development

9. School of Pharmaceutical Sciences

Abstract

This review summarizes recent developments of Brd4 inhibitors and degraders for cancer treatment.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00198G

Reference107 articles.

1. Histone acetyltransferases: function, structure, and catalysis

2. Translating the Histone Code

3. Histone Deacetylases as Targets for Multiple Diseases

4. Bromodomain: an acetyl-lysine binding domain

5. Bromodomains: Structure, function and pharmacology of inhibition

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