Daphnetin contributes to allergen-induced Th2 cytokine expression and type 2-immune responses in atopic dermatitis and asthma

Author:

Zhang Yi1,Qu Lu1,Sun Yun1ORCID,Lin YuPing1ORCID,Zeng Jing2,He LiXia3,Li Xiucun4,Gu Wen1,Nie Jian1,Yu Xiaoling5,Tong XiaoYun6ORCID,Huang Feng17ORCID

Affiliation:

1. School of Pharmaceutical Science, Department of Pharmacology of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China

2. Department of Chinese Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China

3. The Second Affiliated Hospital of Wannan Medical College, Wuhu 241001, China

4. Qi-Lu Hospital of Shandong University, Jinan 250012, China

5. The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650021, China

6. The First Affiliated Hospital of Yunnan University of Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650021, China

7. Yunnan Key Laboratory of Southern Medicinal Utilization, College of Traditional, Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650021, China

Abstract

Daphnetin reduced atopic dermatitis, asthma and PCA symptom. Daphnetin inhibited activation of mast cell. Daphnetin might be a candidate for the treatment of AD.

Funder

National Natural Science Foundation of China

Yunnan Provincial Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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