Biodegradable nano-organosilica gene carrier for high-efficiency gene transfection-Reference-Cited by-同舟云学术

Biodegradable nano-organosilica gene carrier for high-efficiency gene transfection

Published:2020 Issue:12 Volume:8 Page:2483-2494
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Zeng Kun¹²³⁴⁵,Ma Li⁶⁷⁴⁵,Yang Wenxiu¹²³⁴⁵,Lei Shan¹²³⁴⁵,Wang Mozhen¹²³⁴⁵^ORCID,You Yezi¹²³⁴⁵^ORCID,Zhao Yu⁶⁷⁴⁵,Ge Xuewu¹²³⁴⁵

Affiliation:

1. CAS Key Laboratory of Soft Matter Chemistry

2. Department of Polymer Science and Engineering

3. University of Science and Technology of China

4. Hefei

5. China

6. Department of Plastic Surgery

7. First Affiliated Hospital of Anhui Medical University

Abstract

Guanidinated-fluorinated α-polylysine-modified organosilica nanoparticles can form a novel raisin-bread-like gene vector, which is disintegrated in cells by GSH to show high transfection efficiency.

Funder

National Natural Science Foundation of China

China National Funds for Distinguished Young Scientists

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2020/TB/D0TB00108B

Reference67 articles.

1. Overcoming Nonviral Gene Delivery Barriers: Perspective and Future

2. Viral vectors: from virology to transgene expression

3. Synthetic DNA delivery systems

4. Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA

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