Design, synthesis and biological evaluation of dihydro-2-quinolone platinum(iv) hybrids as antitumor agents displaying mitochondria injury and DNA damage mechanism-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of dihydro-2-quinolone platinum(iv) hybrids as antitumor agents displaying mitochondria injury and DNA damage mechanism

Published:2021 Issue:1 Volume:50 Page:362-375
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Liu Zhifang¹²³⁴,Li Zuojie¹²³⁴,Du Tao⁵⁶⁴,Chen Yan¹²³⁴,Wang Qingpeng¹²³⁴^ORCID,Li Guoshuai¹²³⁴,Liu Min¹²³⁴^ORCID,Zhang Ning¹²³⁴^ORCID,Li Dacheng¹²³⁴⁷,Han Jun¹²³⁴

Affiliation:

1. Institute of Biopharmaceutical Research

2. Liaocheng University

3. Liaocheng 252059

4. P.R. China

5. Henkel Loctite China Corp.Ltd

6. Yantai 264006

7. Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology

Abstract

Dihydro-2-quinolone platinum(iv) hybrids exhibit effective antitumor activities by causing serious mitochondria injury and DNA damage, and show great potential in reversing cisplatin resistance and improving antitumor efficacies.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Liaocheng University

Open Project of Shandong Collaborative Innovation Center for Antibody

National Science and Technology Major Project

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D0DT03194A