Elucidation of the mechanisms governing the thermal diastereomerization of bioactive chiral 1,3,4-thiadiazoline spiro-cyclohexyl derivatives towards their anancomeric stereoisomers-Reference-Cited by-同舟云学术

Elucidation of the mechanisms governing the thermal diastereomerization of bioactive chiral 1,3,4-thiadiazoline spiro-cyclohexyl derivatives towards their anancomeric stereoisomers

Published:2016 Issue:75 Volume:6 Page:71262-71272
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Menta S.¹²³⁴,Carradori S.⁵⁶⁷⁴,Siani G.⁵⁶⁷⁴,Secci D.¹²³⁴,Mannina L.¹²³⁴,Sobolev A. P.⁸⁹¹⁰⁴,Cirilli R.¹¹¹²¹³⁴,Pierini M.¹²³⁴^ORCID

Affiliation:

1. Dipartimento di Chimica e Tecnologie del Farmaco

2. Sapienza Università di Roma

3. 00185 Rome

4. Italy

5. Department of Pharmacy

6. “G. D'Annunzio” University of Chieti-Pescara

7. 66100 Chieti

8. Laboratorio di Risonanza Magnetica “AnnalauraSegre”

9. Istituto di Metodologie Chimiche CNR Area della Ricerca di Roma

10. 00015 Monterotondo

11. Dipartimento del Farmaco

12. Istituto Superiore di Sanità

13. 00161 Rome

Abstract

Synthesis of bioactive 1,3,4-thiadiazoline-spiro-cyclohexyl-alkyl-substituted diastereomers by effective switching between kinetic and thermodynamic control.

Funder

Sapienza Università di Roma

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA13727J

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